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A powerful daily combination medicine used to lower high blood pressure when a single drug isn't enough.
Co-Aprovel is a dual-action blood pressure tablet. It combines two different medicines into one single pill to attack high blood pressure from two separate angles:
Irbesartan (150mg): This is an Angiotensin II Receptor Blocker (ARB). It blocks a natural chemical in your body that forces blood vessels to tighten. By blocking it, this medicine co-operates with your vascular system to relax and widen your blood vessels.
Hydrochlorothiazide (12.5mg): This is a mild "water pill" (diuretic). It triggers your kidneys to flush out excess salt and water from your bloodstream through your urine.
Lowering the total amount of fluid moving through your blood vessels combined with keeping the vessels relaxed dramatically drops the pressure, making it much easier for your heart to pump blood.
Stubborn High Blood Pressure (Hypertension): Used when your blood pressure numbers remain too high while taking just one medication (like plain irbesartan or another single drug).
✅ Adults who require a stronger, multi-drug tablet to successfully control their daily blood pressure numbers.
❌ ABSOLUTE PREGNANCY BAN: Never take Co-Aprovel if you are pregnant or planning a pregnancy. The irbesartan component can cause severe, life-threatening damage, skull defects, or death to an unborn baby if taken during pregnancy. If you fall pregnant, stop taking it instantly and contact your clinic.
❌ The Sulfa Allergy Warning: Do not take this medicine if you have a known severe allergy to "sulfa" drugs or sulfonamide antibiotics, as the hydrochlorothiazide component can trigger an allergic shock.
❌ Severe Liver or Kidney Shutdown: Avoid using if your kidneys or liver are experiencing severe structural failure, or if you are entirely unable to pass urine.
The Pack Configuration: Each box contains exactly 28 tablets, providing a complete 4-week (28-day) continuous heart maintenance course.
The Dose: Take exactly 1 tablet daily. It can be swallowed with or without food.
1.Take your tablet first thing in the morning:Timing.
Swallow your tablet whole with a glass of water once daily in the morning (such as with breakfast). Because it contains a mild water pill, taking it in the morning ensures you flush out excess fluids during the day, preventing you from having to wake up multiple times at night to use the bathroom.
2.Rise up very slowly from lying down:Postural shift.
The combination of a vessel relaxer and a water pill can make you feel lightheaded when you first stand up. Always sit on the edge of your bed or chair for 60 seconds before standing to let your circulation adjust safely.
3.Drink plain water consistently:Hydration baseline.
Unless your cardiologist has put you on a strict fluid limit, drink water regularly during the day. This medicine gently removes excess fluid, so staying normally hydrated prevents your blood pressure from dropping too low or causing muscle cramps.
Co-Aprovel is generally very well tolerated, but because it actively shifts fluid and salt balances, you may experience some temporary adjustments:
Mild dizziness, lightheadedness, or feeling tired
Mild nausea or a brief upset stomach
An increase in how often you need to urinate during the first few hours after your dose
Changes in blood mineral levels, such as low potassium or high uric acid (which your doctor will track with routine blood tests)
How long does a 28-tablet box last, and what happens if I run out?
Since you take exactly 1 tablet every day, a box of 28 tablets will last you exactly 4 weeks (28 days). High blood pressure requires continuous, lifelong control. Running out of your medicine can cause your blood pressure to bounce back up sharply within a few days. Always ensure you order your refill a few days before your blister pack runs completely empty.
Can I drink alcohol while taking Co-Aprovel?
It is highly recommended to strictly limit or avoid alcohol while on this medication. Alcohol relaxes blood vessels on its own. Combining it with Co-Aprovel can cause an abrupt, severe drop in your blood pressure, leaving you feeling profoundly dizzy, weak, or prone to fainting when you stand up.
What should I do if I miss a morning dose?
If you remember before afternoon, take your tablet immediately. If it is already late in the evening or close to your next day's morning dose, skip the missed tablet entirely and just take your regular pill the next morning. Never take a double dose (two tablets at once) to make up for a forgotten time.
How can I get original Co-Aprovel delivered?
Because Co-Aprovel is a high-potency combination prescription medicine, it cannot be bought over the counter. We deliver authentic, original manufacturer-batch Sanofi Co-Aprovel (150mg/12.5mg) boxes straight to your home, office, or clinic across Nigeria via Sanlive Pharmacy, keeping your daily heart and blood pressure management perfectly seamless.
100% genuine combination cardiovascular prescription medication. Quality-verified, batch-tracked, and dispensed strictly under legal healthcare guidelines by licensed pharmacists at Sanlive Pharmacy.
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