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A high-potency, prescription-only antimalarial therapy designed as a rapid 3-day treatment course to eliminate uncomplicated malaria infections caused by the Plasmodium falciparum parasite.
Coartem 80/480 combines two active antimalarial agents that work together to rapidly clear parasites from the bloodstream: Artemether (80mg) and Lumefantrine (480mg).
They eliminate the infection through a coordinated dual-action mechanism:
Rapid Parasite Clearance (Artemether): Artemether is an artemisinin derivative that absorbs rapidly into the body. It interacts with the iron inside the malaria parasite, generating highly reactive free radicals that instantly damage and destroy the parasite's internal cellular structures. This quickly drops the initial parasite load and relieves early symptoms like fever and chills.
Long-Term Elimination (Lumefantrine): Lumefantrine clears out of the body much more slowly. It remains in the bloodstream for days, systematically hunting down and destroying any remaining parasites that survived the initial wave, completely curing the infection and preventing a malaria relapse.
Uncomplicated Falciparum Malaria: Treating acute, uncomplicated malaria infections caused by Plasmodium falciparum in adults and children weighing 35kg or more.
Chloroquine-Resistant Malaria: Effectively clearing malaria strains that have developed resistance to older, traditional antimalarial treatments like chloroquine.
Severe or Complicated Malaria: Do not use this oral tablet if you have signs of severe, life-threatening malaria (such as cerebral malaria, severe anemia, persistent vomiting, or an inability to swallow). These conditions require immediate hospitalization and intravenous (IV) medication.
Heart Rhythm Issues: Avoid this medication if you or anyone in your family has a history of long QT syndrome, severe heart arrhythmias, or slow heart rate (bradycardia), as lumefantrine can occasionally affect electrical heart rhythms.
Pregnancy: If you are in your first trimester of pregnancy, talk to your doctor immediately. Coartem is standardly used in the second and third trimesters, but alternative treatments are sometimes preferred during the early stages of pregnancy.
The 3-Day Rule: Coartem 80/480 is a strict 6-dose treatment course spread over exactly 3 consecutive days. You must finish all 6 doses even if you start feeling completely healthy after the first day. Leaving the course unfinished can cause the malaria to return much stronger.
The Fatty Food Law: You must take each dose alongside a meal, milk, or a small snack containing fat (such as food cooked with oil or butter). Fat is absolutely necessary for your digestive tract to absorb the lumefantrine properly; taking it on a completely empty stomach will make the treatment far less effective.
(For adults and adolescents weighing 35kg and above)
| Day | Dose Timing | Number of Tablets |
| Day 1 | Immediately upon diagnosis / first dose | 1 Tablet |
| Exactly 8 hours after your first dose | 1 Tablet | |
| Day 2 | Morning (approx. 24 hours after the very first dose) | 1 Tablet |
| Evening (exactly 12 hours after the morning dose) | 1 Tablet | |
| Day 3 | Morning (approx. 48 hours after the very first dose) | 1 Tablet |
| Evening (exactly 12 hours after the morning dose) | 1 Tablet |
If you vomit within 1 hour of swallowing a Coartem tablet, you must take a replacement tablet immediately to ensure your body gets the right amount of medicine. If you vomit up the second replacement tablet, contact your doctor or pharmacist right away for an alternative treatment layout.
While highly effective and generally well-tolerated, Coartem can occasionally prompt temporary adjustments as it fights the infection:
Mild headaches, occasional dizziness, or a brief feeling of physical weakness.
Digestive shifts, including nausea, mild stomach aches, vomiting, or a temporary loss of appetite.
Muscle aches, joint pain, or temporary sleep issues.
Note: Many of these side effects mimic the actual symptoms of malaria, and they typically fade away completely as the parasites leave your system.
Can I take Coartem to prevent catching malaria before traveling to a high-risk area?
No. Coartem is strictly a curative treatment designed to kill active parasites already living in your blood. It is not a preventative medication (prophylaxis) and will not protect you from being bitten by mosquitoes. For malaria prevention, ask your pharmacist or doctor about daily or weekly preventative pills like doxycycline or mefloquine.
Can I take standard pain relievers like paracetamol alongside Coartem?
Yes, absolutely. If you are experiencing a high fever, severe body aches, or throbbing headaches from malaria, it is completely safe to take paracetamol alongside your Coartem doses to manage the discomfort while the antimalarial goes to work.
What should I do if I accidentally miss a scheduled dose?
Take the missed dose as soon as you remember, and then space out your remaining doses according to the standard 12-hour gap intervals. Do not double the dose to make up for a forgotten turn, as this can strain your system.
You can purchase genuine, factory-sealed Coartem 80/480mg Tablets online through Sanlive Pharmacy & Stores for secure payment and fast, reliable same-day delivery directly to your home, office, or clinic within Lagos, Abuja, and Port Harcourt.
Important Notice: This information is for educational support purposes only. Coartem is a high-potency antimalarial medication that must be used strictly following a laboratory-confirmed malaria diagnosis (such as a rapid diagnostic test or a blood film microscopy smear). If your symptoms worsen or do not begin to clear within 48 hours, seek immediate medical attention from a physician.
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