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Treviamet 50mg/1000mg is a prescription high-strength, dual-action oral diabetes medication. Each film-coated tablet contains a fixed-dose combination of two active ingredients: 50mg of Sitagliptin (as phosphate monohydrate) and a maximum-strength 1000mg of Metformin Hydrochloride. The "TP 35's" designation indicates a specific pack configuration containing exactly 35 tablets (typically structured as 5 blister strips of 7 tablets each).
Taken by mouth exactly as directed by a healthcare professional, adults use it alongside a healthy diet and regular exercise to manage and lower blood sugar metrics in Type 2 Diabetes.
Type 2 Diabetes occurs when your body does not make enough insulin or cannot properly use it, leading to elevated blood sugar levels. Treviamet targets this metabolic issue from two distinct angles:
Sitagliptin (The Smart Insulin Booster): This component is a DPP-4 inhibitor. It protects natural hormones in your body called incretins. These hormones signal your pancreas to produce and release more insulin, but only when your blood sugar rises after eating. It also tells your liver to stop releasing unnecessary extra glucose.
Metformin (The Muscle & Liver Optimizer): This component belongs to the biguanide family. It works by making your muscles and fat cells highly sensitive to insulin, allowing them to pull sugar out of your blood and use it for energy more efficiently. It also significantly reduces the amount of sugar absorbed from your food and stops your liver from creating excess glucose.
Combined Performance: By pairing these two medicines, Treviamet helps keep your fasting and post-meal blood sugar levels highly stable, lowering your long-term HbA1c metrics.
🚨 Critical Safety Warning: Treviamet contains a high dose of Metformin (1000mg), which can cause a rare but extremely serious, life-threatening condition called Lactic Acidosis if your kidneys are strained.
Lactic acidosis is a dangerous buildup of acid in your blood. Because Metformin is flushed out entirely through your kidneys, you must strictly not take Treviamet if you have severe kidney failure or a heavily reduced kidney filtration rate (e.g., eGFR below 30 mL/min).
The Alcohol Rule: You must strictly avoid heavy, binge drinking or chronic alcohol intake while taking this medicine. Alcohol drastically increases the risk of lactic acidosis and can cause your blood sugar to drop dangerously low.
Signs of Trouble: If you experience deep, rapid breathing, severe muscle cramps, extreme tiredness, persistent nausea, vomiting, or a sudden slow heartbeat, stop taking the medicine immediately and go to the nearest hospital emergency room.
Severe Stomach and Pancreas Pain: The Sitagliptin component can rarely cause inflammation of the pancreas (pancreatitis). If you develop severe, constant abdominal pain that shoots straight through to your back, accompanied by vomiting, stop using this medicine immediately and see your doctor.
Contrast Dye Scans: If you need an X-ray, CT scan, or MRI that requires an injection of an iodinated contrast dye into your veins, you must temporarily stop taking Treviamet at the time of the test and wait at least 48 hours afterward. This is because contrast dye can temporarily reduce kidney function, causing Metformin to build up in your blood.
Type 1 Diabetes Restriction: Treviamet is strictly not for individuals with Type 1 Diabetes or diabetic ketoacidosis, as it requires a functioning pancreas to work.
Pregnancy and Nursing: This medication is not recommended for pregnant or breastfeeding women. Alternative blood sugar management therapies, such as insulin, are clinically preferred during pregnancy.
The Normal Amount: Because this specific tablet contains a high dose of 1000mg of Metformin, the standard routine frequently involves taking 1 tablet twice a day (for example, one with breakfast and one with dinner) to hit the standard 2000mg maximum daily Metformin threshold. Always follow your doctor's exact prescription.
The Solid Meal Rule: You must strictly take your Treviamet tablet right alongside your main meals (never on an empty stomach). Taking a 1000mg Metformin dose on an empty stomach can trigger immediate, intense stomach churning, severe nausea, or diarrhea. Food acts as a perfect physical buffer for your stomach lining.
Swallow Whole: Swallow your tablet completely whole with a full glass of plain water. Do not chew, break, or crush it.
| Dose | Timing | How to Take |
| Morning Dose | Immediately after starting breakfast | Swallow 1 tablet whole with water. Do not take it on an empty stomach. |
| Evening Dose | Immediately after starting dinner | Swallow 1 tablet whole. Maintain a consistent daily schedule. |
| Monitoring | Routine tracking | Check your blood sugar metrics as directed and drink plenty of water daily. |
As your gastrointestinal system adapts to this high-strength blood sugar-lowering formulation, you may notice a few temporary updates, which typically improve after the first few weeks:
Nausea, a brief upset stomach, mild stomach gas, abdominal bloating, or temporary diarrhea.
A brief, metallic taste in your mouth shortly after swallowing.
Mild nasal congestion, a runny nose, or a sore throat.
Low Blood Sugar Notice: Treviamet rarely causes low blood sugar (hypoglycemia) when used on its own. However, if your doctor pairs it with insulin or a sulfonylurea pill (like Glimepiride), sugar crashes can happen. Always keep a fast-acting sugar source, like fruit juice or glucose tablets, nearby.
What should I do if I accidentally forget to take my scheduled tablet?
Take your missed tablet with food as soon as you remember. However, if it is already almost time for your next scheduled mealtime dose, skip the forgotten tablet completely and just take your regular tablet with your meal. Never take 2 tablets at the exact same time to make up for a missed one, as doubling this high-strength dose can cause severe stomach cramps or a dangerous blood sugar crash.
Can long-term use of this medicine cause a vitamin deficiency?
Yes, it can. The Metformin component inside Treviamet can gradually lower your body's ability to absorb Vitamin B12 from your food over several years. A prolonged deficiency can lead to tiredness or mild nerve tingling in your toes. Your doctor can track your blood metrics annually and may suggest a simple daily Vitamin B12 supplement if needed.
How should the 35-tablet packs be stored safely?
Keep your tablets sealed flat inside their original factory foil blisters to protect them from tropical humidity and ambient moisture. Store the box in a cool, dry room strictly below 30°C, away from hot kitchen appliances, damp bathrooms, or direct window sunlight, and keep it safely out of the reach of children.
To ensure you are purchasing 100% genuine, NAFDAC-authenticated Treviamet 50mg/1000mg Tablets (35's) (handled safely away from extreme tropical storage heat so the active ingredients stay stable and fully effective for your blood sugar control), you can order directly online through Sanlive Pharmacy & Stores. We provide verified safe clinical handling, secure digital payment networks, and fast delivery straight to your home or office anywhere in Nigeria.
Notice: This guide is for educational and general medication tracking support only. Managing Type 2 Diabetes requires regular, professional clinical monitoring and routine HbA1c laboratory testing by a doctor. If someone accidentally swallows a massive overdose of tablets all at once, experiences signs of lactic acidosis (deep rapid breathing, severe vomiting, slow heartbeat), or shows signs of an immediate allergic shock (such as a sudden widespread rash, swelling of the face, lips, and throat with breathing distress), stop use immediately and go to the nearest hospital emergency room right away.
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