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HIGH-EFFICIENCY ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITOR DESIGNED FOR ROBUST BLOOD PRESSURE REGULATION, POST-MYOCARDIAL INFARCTION STABILIZATION, AND RENAL PROTECTION. DELIVERED SECURELY ACROSS NIGERIA AND WORLDWIDE.
Zestril contains Lisinopril, a potent, long-acting Angiotensin-Converting Enzyme (ACE) inhibitor. At a molecular level, it blocks the catalytic enzyme responsible for converting Angiotensin I into Angiotensin II—a powerful endogenous hormone that aggressively constricts blood vessels and signals the adrenal glands to release aldosterone.
By shutting down this pathway, Zestril triggers widespread relaxation and widening of the arteries (vasodilation). This structural decompression directly reduces peripheral arterial resistance, lowers systemic blood pressure, and decreases the mechanical workload (afterload) placed on the heart muscle.
Essential Hypertension: Lowering elevated blood pressure to safe clinical targets, protecting vital target organs from long-term damage.
Heart Failure Management: Utilized alongside diuretics and beta-blockers to improve survival rates, maximize exercise tolerance, and decrease hospitalization frequency.
Post-Myocardial Infarction (Heart Attack) Care: Initiated within 24 hours of stabilization to prevent left ventricular remodeling (unwanted stretching or thinning of the heart wall) and improve overall survival outcomes.
Diabetic Nephropathy: Shielding the kidneys in hypertensive patients with Type 2 Diabetes, significantly slowing the progression of renal damage and microalbuminuria (excessive protein leaking into the urine).
✅ Adult Patients requiring a highly stable, once-daily medication to bring high blood pressure under control and protect cardiac or kidney architecture.
❌ CRITICAL CONTRAINDICATION (PREGNANCY): Zestril must never be taken during pregnancy. Inhibiting the renin-angiotensin system during the second and third trimesters can cause severe fetal injury, skull deformities, kidney failure, or fetal death. Discontinue therapy immediately if pregnancy is detected.
❌ Do not use if you have a history of swelling of the deep skin layers or throat (angioedema) triggered by previous ACE inhibitor treatments, or if you have bilateral renal artery stenosis (severe narrowing of the main arteries supplying both kidneys).
Standard Starting Dose: The typical initial dose for hypertension is 10mg taken once daily. Your physician may titrate this dose upwards over time based on your clinical blood pressure readings.
Administration: Swallow the tablet whole with a full glass of water. It can be taken with or without food.
💡 Take your Zestril tablet at the exact same time every day. Unlike some blood pressure medications that require specific timing, Zestril provides a smooth, continuous 24-hour therapeutic effect, making consistency the most important factor in your daily routine.
Lisinopril (10mg as dihydrate): A highly water-soluble, non-prodrug ACE inhibitor that does not require conversion by the liver to become active, ensuring predictable absorption.
Zestril is highly effective and universally trusted. The most common side effect is a dry, tickly, non-productive cough, which is caused by an accumulation of a natural peptide called bradykinin in the respiratory tract. Other mild reactions include dizziness or lightheadedness as the body adapts to lower pressure, headaches, or fatigue.
⚠️ CLINICAL MONITORING NOTE: Because Zestril helps the body retain potassium while lowering blood pressure, your doctor will order regular blood tests to track your kidney function and serum potassium levels. Avoid using potassium supplements or low-sodium salt substitutes containing potassium chloride without explicit medical clearance, as this can lead to dangerously elevated potassium levels (hyperkalemia).
What should I do if I develop a persistent dry cough while taking Zestril?
The "ACE inhibitor cough" is a well-documented side effect that occurs in a small percentage of patients. It is entirely harmless and does not respond to standard over-the-counter cough syrups. If the tickling cough becomes highly disruptive or affects your sleep, notify your physician—they can easily transition you to an alternative class of medication, such as an Angiotensin II Receptor Blocker (ARB), which carries no cough risk.
Why do I feel slightly dizzy when rising out of bed in the morning?
This temporary lightheadedness is known as orthostatic hypotension and can occasionally happen during the first couple of weeks of starting Zestril or after a dose increase. To stay perfectly safe and comfortable, make a habit of rising very slowly from a lying or sitting position, pausing on the edge of the bed for a moment to allow your circulatory system to smoothly adjust.
Can I take over-the-counter anti-inflammatory drugs like Ibuprofen for a headache while on Zestril?
You should strictly avoid the regular or prolonged use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like Ibuprofen, Diclofenac, or Naproxen while on Zestril. NSAIDs cause the body to retain fluids and narrow blood vessels in the kidneys, which directly counteracts the blood pressure-lowering benefits of Zestril and can significantly increase the risk of acute kidney strain. Opt for paracetamol for minor aches.
Do you ship premium cardiovascular therapies internationally?
Yes. We deliver genuine, batch-verified prescription heart and blood pressure formulations to the UK, USA, Canada, Europe, and across Africa in highly secure, protective medical packaging.
Is it available for home delivery across Nigeria?
Yes. We supply to all 36 states, with premium express same-day shipping options available throughout residential and corporate addresses in Lagos and Abuja via Sanlive Pharmacy to ensure your daily cardiovascular care remains unbroken.
100% genuine premium pharmaceutical. Dispensed by PCN-licensed pharmacists at Sanlive Pharmacy
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