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Urofollitropin 75 IU is a prescription-only, high-potency gonadotrophin hormone medication. It contains Highly Purified (HP) Follicle-Stimulating Hormone (FSH) extracted from natural human menopausal sources.
It is administered via a Subcutaneous (S.C.) or Intramuscular (IM) injection. In clinical reproductive medicine, it acts as a direct biological growth signal to stimulate the ovaries to produce and mature healthy egg follicles.
(Note: Urofollitropin contains strictly active FSH, unlike hMG which contains a mix of FSH and LH, and unlike hCG which acts as the final "trigger shot").
Urofollitropin replicates the master signals naturally sent by the brain’s pituitary gland to kick-start follicle growth:
Direct Follicle Recruitment: It binds directly to FSH receptors on the surface of cells inside the ovaries, signaling the body to recruit, grow, and mature fluid-filled sacs called follicles, which house individual eggs.
Drives Estrogen Production: As the follicles expand under the influence of the 75 IU dose, they secrete increasing levels of estrogen, which thickens the lining of the uterus to prepare the body for a successful pregnancy.
The "Highly Purified" (HP) Matrix: Modern purification screening filters out practically all traces of raw urinary proteins and other gonadotrophins (like LH). This specific isolation drastically minimizes local skin stinging and makes subcutaneous home injection comfortable.
Anovulatory Infertility: Inducing egg development in women who do not ovulate naturally or who have irregular cycles, particularly those living with Polycystic Ovary Syndrome (PCOS) who have not responded to baseline oral pills (like clomifene citrate).
Assisted Reproductive Technology (ART/IVF): Stimulating the development of multiple egg follicles simultaneously (controlled ovarian hyperstimulation) so they can be surgically harvested for In Vitro Fertilization or ICSI cycles.
A fertility specialist will review structural ultrasound scans and baseline blood work to rule out specific exclusion parameters before starting:
Hormone-Dependent Malignancies: Strictly contraindicated in patients with active tumors of the uterus, ovaries, breast, or master glands in the brain (hypothalamus or pituitary gland).
Primary Ovarian Failure: It will not be clinically effective if the ovaries have completely ceased functioning naturally (such as early menopause or a high baseline natural FSH blood count).
Unexplained Vaginal Bleeding: If you are experiencing unusual pelvic bleeding that has not been diagnosed, therapy lines must be delayed.
Pregnancy and Breastfeeding: Urofollitropin is highly unsafe and strictly contraindicated once pregnancy is achieved. It is used solely to facilitate conception and must be discontinued immediately upon a positive test.
Strictly Customized Dosing: Urofollitropin is never given on a fixed, generic calendar. Your daily dose and the number of 75 IU vials mixed are calculated dynamically by your specialist based on routine pelvic ultrasounds and blood estrogen metrics.
The Companion Trigger Law: While Urofollitropin safely grows and matures the follicles, it does not release them. Once ultrasound scans confirm your follicles have reached the target size, your specialist will stop the urofollitropin and prescribe a separate single injection of Human Chorionic Gonadotrophin (hCG) exactly 24 to 36 hours later to trigger ovulation.
The Reconstitution Process: It is supplied as a dry lyophilized powder vial alongside a separate ampoule of sterile liquid solvent (Normal Saline). Once dissolved gently, it can be given via two professional routes:
Subcutaneous (S.C.) Injection: Injected into the fat layer under the skin, standardly in the lower abdomen or thigh. This is the preferred route for home self-injection.
Intramuscular (IM) Injection: Injected deeply into a large muscle mass.
1.Dissolve the 75 IU powder using the solvent:Reconstitution.
Draw up the supplied liquid solvent using a sterile syringe and inject it smoothly into the dry powder vial. Swirl it gently until the cake completely dissolves. Do not shake vigorously.
2.Verify the liquid is clear and air-free:Visual Clearance.
Inspect the mixed liquid. It must be completely clear and colorless with no un-dissolved floating particles. Draw the dose back into the syringe and tap gently to clear any air bubbles.
3.Pinch the skin and deliver the subcutaneous dose:Injection Mechanics.
Clean the skin site with an alcohol swab and let it dry completely. Pinch a fold of skin on your lower abdomen, insert the short needle smoothly at a 90-degree angle, and press the plunger. Rotate injection sites daily.
4.Discard the used components into a sharps container:Safe Disposal.
Withdraw the needle smoothly and place the single-use syringe and glass vials immediately into a puncture-proof sharps disposal bin. Never recap or reuse the needle.
As your reproductive tract responds to the targeted follicle recruitment, you may notice typical updates:
Minor soreness, localized redness, mild bruising, or transient swelling at the skin site where the needle entered.
Pelvic Bloating and Cramping: A feeling of lower abdominal fullness or mild aching as multiple follicles naturally expand inside the ovaries.
Systemic changes, including mild headaches, transient hot flushes, mild nausea, or a feeling of fatigue.
What is Ovarian Hyperstimulation Syndrome (OHSS), and what are the warning signs?
OHSS is a serious medical complication that can occur if the medication over-stimulates the ovaries, causing them to swell rapidly and leak fluid into the abdomen. You must contact your fertility clinic or seek emergency medical care immediately if you develop severe pelvic pain, extreme stomach bloating, rapid weight gain over 24 to 48 hours, persistent vomiting, severe dizziness, or sudden difficulty breathing.
Does treatment with Urofollitropin raise the chances of multiple births?
Yes, significantly. Because FSH drives the maturation of multiple follicles simultaneously, the risk of a multiple pregnancy (such as twins or triplets) is much higher compared to natural conception. Your specialist will monitor your daily follicle growth closely via ultrasound scans to manage this risk safely.
How should the unopened 75 IU vials be stored at home?
To preserve the delicate protein structure of the hormone, unopened boxes should be stored inside a refrigerator strictly between 2°C and 8°C, ensuring they never freeze. Alternatively, certain validated brands allow for cool room storage strictly below 25°C away from direct sunlight; check your specific box packaging for exact guidance. Once mixed with the solvent, the solution must be used immediately.
Advanced fertility treatments and highly purified gonadotrophin proteins require continuous climate-controlled cold-chain logistics ($2^{\circ}\text{C}$ to $8^{\circ}\text{C}$), absolute supply chain verification, and strict batch tracking to protect ingredient activity and safeguard your reproductive care. Hospital procurement managers, specialized fertility clinics, and individual patients can securely submit specialized prescriptions and buy genuine, factory-authenticated Urofollitropin 75 IU Injections online through Sanlive Pharmacy & Stores for verified payment and rapid, temperature-secured, cold-chain validated delivery directly to your home, office, or clinical suite within Lagos, Abuja, Port Harcourt, and nationwide via our dedicated specialty clinical distribution networks.
Important Notice: This information is for educational and institutional procurement support purposes only. Urofollitropin 75 IU is a high-potency, prescription-only gonadotrophin hormone. Your entire treatment protocol, daily dose titrations, and routine follicle monitoring (via pelvic ultrasounds and blood hormone draws) must be managed exclusively under the direct physical care of a registered Reproductive Endocrinologist or Fertility Specialist. If a patient experiences sudden severe lower abdominal pain, rapid abdominal swelling, severe dizziness, or breathing difficulties, contact your specialist team immediately or go straight to the nearest hospital emergency room.
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