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Fosfomycin Trometamol is a prescription-strength, broad-spectrum antibiotic. It is typically packaged as a single-dose sachet containing 3g of Fosfomycin (as fosfomycin trometamol) to be dissolved in water.
It is primarily indicated for the single-dose treatment of acute, uncomplicated lower urinary tract infections (cystitis) in women and adolescent girls, as well as for prophylaxis against urinary tract infections prior to transrectal prostate biopsies or urinary surgical procedures in men.
Fosfomycin operates through a unique, targeted mechanism of action:
Inhibits Cell Wall Synthesis: It inhibits the bacterial enzyme MurA (UDP-$N$-acetylglucosamine enolpyruvyl transferase), preventing the first step in bacterial cell wall construction and killing sensitive bacteria (E. coli, Enterococcus, Proteus, etc.).
Prevents Bacterial Adhesion: It reduces the ability of bacteria to adhere to the mucosal lining of the bladder and urinary tract walls.
High Concentration in Urine: A single 3g oral dose is rapidly absorbed and excreted into the urinary tract, maintaining therapeutic antibacterial concentrations in the urine for 24 to 48 hours.
Usage Caution: Fosfomycin is designed as a single-dose treatment for uncomplicated cystitis. Taking extra doses without explicit medical instructions will not increase efficacy and can increase side effects.
Limitation of Use: Fosfomycin is not recommended for treating pyelonephritis (kidney infections) or complicated urinary tract infections, as tissue concentrations in the kidneys are lower than in the bladder.
Superinfection Warning: Like other antibiotics, fosfomycin can alter normal intestinal flora, potentially causing mild to severe antibiotic-associated diarrhea.
Standard Dosage (Acute Uncomplicated Cystitis):
Adult Women & Adolescents: Take one 3g sachet as a single dose.
How to Prepare and Take:
Dissolve the entire contents of 1 sachet into half a glass of cold water (or non-alcoholic beverage) and stir until fully dissolved.
Drink immediately after preparation.
Take on an empty stomach (either 2 hours before or 2 hours after a meal), preferably at bedtime after emptying the bladder.
Fosfomycin Trometamol is generally well-tolerated. Common, mild side effects can include:
Diarrhea or loose stools.
Mild nausea or indigestion.
Headache or mild dizziness.
Mild vulvovaginitis (yeast infection).
Store in a cool, dry place below 30°C.
Keep sachets sealed in their original outer carton to protect from moisture.
Keep strictly out of reach of children.
While the antibiotic begins killing bladder bacteria within hours, symptoms like burning and urinary urgency usually take 24 to 48 hours to resolve as the bladder lining heals.
Fosfomycin is frequently prescribed during pregnancy for uncomplicated cystitis when clinically needed, as single-dose therapy minimizes drug exposure. Always consult your doctor or obstetrician before use.
Co-administration with motility drugs like metoclopramide lowers blood and urine concentrations of fosfomycin by speeding up gastric emptying. Space these medications apart or consult your pharmacist.
You can order verified, original prescription antibiotics like Fosfomycin Trometamol Powder directly online from Sanlive Pharmacy & Stores.
We offer fast doorstep delivery across Nigeria, as well as international shipping to the UK, US, Europe, Middle East, and other parts of the world.
Notice: This guide is for educational information only. Fosfomycin is a prescription antibiotic and must be used strictly under the direction of a licensed healthcare provider.
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