We are your trusted health partner. Local doorstep deliveries is within the hour .We are Licensed and Regulated by the Pharmacist's Council of Nigeria(PCN).Prices displayed here may differ due to inflation.
Piperacillin and Tazobactam is a prescription-only broad-spectrum combination antibiotic administered via intravenous (IV) infusion. It is commonly available in a 8:1 fixed ratio (such as 2.25g, 3.375g, or 4.5g vials, where a 4.5g vial contains 4g of piperacillin and 0.5g of tazobactam).
It is indicated for the treatment of moderate-to-severe bacterial infections across multiple organs, including intra-abdominal infections, severe hospital-acquired or community-acquired pneumonia, complicated urinary tract infections (UTIs), skin and soft tissue infections, and gynecologic or pelvic infections.
This medication combines an extended-spectrum penicillin with a protective enzyme inhibitor:
Piperacillin (Extended-Spectrum Penicillin): Inhibits bacterial cell wall synthesis, causing cell breakdown and death across a wide variety of Gram-positive, Gram-negative, and anaerobic bacteria.
Tazobactam ($\beta$-Lactamase Inhibitor): Neutralizes $\beta$-lactamase enzymes produced by resistant bacteria. This prevents the degradation of piperacillin and extends its antibacterial spectrum.
Severe Hypersensitivity: Do not use if you have a history of severe allergic reactions (anaphylaxis) to penicillins, cephalosporins, or $\beta$-lactamase inhibitors. Seek immediate emergency care if skin rash, swelling, or breathing difficulty occurs.
Renal Adjustment Needed: Dosage adjustments are required for patients with renal impairment or kidney disease. Concomitant use with vancomycin may also increase the risk of acute kidney injury.
Superinfection Alert: Like all broad-spectrum antibiotics, this combination can alter intestinal flora and lead to severe Clostridioides difficile-associated diarrhea. Contact a doctor if severe, watery diarrhea occurs during or after treatment.
Administration: Administered strictly as an intravenous (IV) infusion over 30 minutes (or extended infusion over 3 to 4 hours) by a trained healthcare professional in a clinic or hospital setting.
Standard Adult Dosing:
Usual Dosage: 3.375g every 6 hours, or 4.5g every 6 hours for severe infections (such as hospital-acquired pneumonia).
Duration: Typically ranges from 7 to 14 days depending on infection severity and clinical response.
Reconstitution: Reconstitute with compatible diluents (such as 0.9% Sodium Chloride or Sterile Water for Injection) prior to infusion.
Piperacillin and Tazobactam is generally well-tolerated in clinical settings. Side effects may include:
Mild diarrhea, constipation, or nausea.
Headache or insomnia.
Infusion site reactions (phlebitis, pain, or redness).
Mild skin rash or itching.
Store dry powder vials at controlled room temperature below 25°C or 30°C.
Keep vials inside their outer carton to protect from light.
Once reconstituted, use immediately or follow strict institutional storage guidelines for refrigerated solutions.
Keep strictly out of reach of children.
No. Piperacillin and tazobactam are not absorbed through the gastrointestinal tract and are available exclusively as an injectable IV formulation.
Yes, but it should not be physically mixed or co-infused in the same IV line with aminoglycosides (like gentamicin or tobramycin) because physical inactivation can occur. They must be administered separately.
It should only be used during pregnancy if clearly needed and prescribed by a physician after evaluating the potential benefits and risks.
You can order verified, original prescription hospital medications like Piperacillin and Tazobactam Injection directly online from Sanlive Pharmacy & Stores with a valid medical order.
We offer fast, secure delivery across Nigeria, as well as international shipping to the UK, US, Europe, Middle East, and other parts of the world.
Notice: This guide is for simple educational information only. Piperacillin and Tazobactam is a prescription-only intravenous antibiotic and must be administered under the direct supervision of a licensed healthcare provider.
No reviews yet — be the first!
Log in to write a review.
