Panadol Night Pain is an over-the-counter nighttime dual-action pain reliever and sleep aid manufactured by GSK / Haleon. The 20-tablet pack contains two active ingredients per tablet: 500mg of Paracetamol (Acetaminophen) and 25mg of Diphenhydramine Hydrochloride.
It is formulated for the nighttime relief of mild to moderate pain—such as headaches, migraines, backache, rheumatic and muscle pain, toothaches, or period pain—that causes difficulty falling asleep.
Panadol Night Pain provides dual-action relief to help you rest and recover overnight:
Targeted Pain Relief (Paracetamol 500mg): Blocks prostaglandin synthesis in the central nervous system to stop pain signals and lower fever.
Sedative Sleep Aid (Diphenhydramine 25mg): An antihistamine that crosses the blood-brain barrier to produce a mild, temporary sedative effect, helping you fall asleep easily despite discomfort.
Drowsiness Warning: Do not take during the day. Diphenhydramine causes pronounced drowsiness. Do not drive, operate machinery, or perform hazardous tasks after taking this medication.
Paracetamol Overdose Risk: Never take more than 2 tablets at night, and do not exceed 8 total paracetamol-containing tablets (4000mg) across any 24-hour period. Excessive paracetamol can cause severe liver damage.
Avoid Combination Use: Do not take alongside any other medications containing paracetamol or antihistamines (including cough, cold, or allergy drugs). Avoid drinking alcohol while taking this medicine, as alcohol enhances sedation and drowsiness.
Recommended Dosage for Adults and Adolescents (Aged 16 Years & Older):
Take 2 tablets 20 to 30 minutes before bedtime.
Leave at least 4 hours between taking daytime paracetamol and taking Panadol Night Pain.
Do not take for more than 7 consecutive nights without medical consultation.
Recommended Dosage for Adolescents (Aged 12 to 15 Years):
Take 1 tablet 20 to 30 minutes before bedtime.
Age Limit: Do not give to children under 12 years of age.
How to Take: Swallow whole with a glass of water. Can be taken with or without food.
Panadol Night Pain is well-tolerated, though side effects related to diphenhydramine can occur:
Drowsiness, grogginess, or morning tiredness.
Dry mouth, nose, or throat.
Mild dizziness, head heaviness, or blurred vision.
Mild stomach upset or constipation.
Store in a cool, dry place below 25°C or 30°C.
Keep tablets sealed in their original blister pack inside the box to protect from moisture and light.
Keep strictly out of reach of children.
No. Panadol Night Pain contains diphenhydramine, which causes significant drowsiness. It is strictly meant for bedtime use to help relieve pain that interferes with sleep.
Yes, provided you do not exceed 8 total tablets (4000mg of paracetamol) in a 24-hour period. For example, you can take standard paracetamol during the day and 2 Panadol Night tablets before bed, ensuring at least 4 hours between doses.
Panadol Night Pain is not recommended during pregnancy or breastfeeding without explicit advice from your doctor or midwife, due to the diphenhydramine component.
You can order verified, original healthcare products like Panadol Night Pain Tablets (20s Pack) directly online from Sanlive Pharmacy & Stores.
We offer fast doorstep delivery across Nigeria, as well as international shipping to the UK, US, Europe, Middle East, and other parts of the world.
Notice: This guide is for simple educational information only. Always read the packaging leaflet carefully. If nighttime pain or insomnia persists for more than 7 days, consult a physician or pharmacist.
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